Serine/Threonine-Protein Kinase SIK2

Preferred Label : Serine/Threonine-Protein Kinase SIK2;

NCIt synonyms : Qin-Induced Kinase; Serine/Threonine-Protein Kinase SNF1-Like Kinase 2; EC 2.7.11.1; SIK-2; Salt-Inducible Serine/Threonine Kinase 2; Salt-Inducible Protein Kinase 2; SNF1-Like Kinase 2;

NCIt definition : Serine/threonine-protein kinase SIK2 (926 aa, 104 kDa) is encoded by the human SIK2 gene. This protein plays a role in protein phosphorylation that affects insulin signaling and mitosis.;

NCIt note : Therapies that interfere with activity of serine/threonine-protein kinase SIK2 results in loss of normal mitotic spindle-driven chromosome separation and increased sensitivity to antitumor drugs.;

Details

Origin ID

C92520;

UMLS CUI

C2973380;

OMIM relation
- Salt-inducible kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- salt-inducible kinase-2, human [MeSH concept]
- salt-inducible kinase-2, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- SIK2 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- LKB1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Salt-inducible Kinase Inhibitor GRN-300 [NCIt concept]

Keyword's position in hierarchy(ies) :

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