TP53INP1 wt Allele

Preferred Label : TP53INP1 wt Allele;

NCIt synonyms : TP53INP1A; SIP; TP53DINP1; FLJ22139; TP53INP1B; p53DINP1; Tumor Protein p53 Inducible Nuclear Protein 1 wt Allele; DKFZp434M1317; Teap;

NCIt definition : Human TP53INP1 wild-type allele is located in the vicinity of 8q22 and is approximately 23 kb in length. This allele, which encodes tumor protein p53-inducible nuclear protein 1, is involved in the promotion of apoptosis in response to DNA damage. Aberrant expression of the gene is associated with pancreatic ductal adenocarcinomas and HTLV-related T cell leukemia.;

NCIt note : Expression of the TP53INP1 gene can be induced by adriamycin, gamma irradiation and hydrogen peroxide, in a p53-dependent way. Lower expression levels are induced by ultraviolet radiation. (UniProt); The TP53INP1 gene has two distinct products that are the result of alternative splicing.;

GenBank Accession Number : AF409115;

Details

Origin ID

C92491;

UMLS CUI

C2985139;

OMIM relation
- Tumor protein p53-inducible nuclear protein 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 8q22 [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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