NCIt synonyms : TP53INP1A; SIP; TP53DINP1; FLJ22139; TP53INP1B; p53DINP1; Tumor Protein p53 Inducible Nuclear Protein 1 wt Allele; DKFZp434M1317; Teap;
NCIt definition : Human TP53INP1 wild-type allele is located in the vicinity of 8q22 and is approximately
23 kb in length. This allele, which encodes tumor protein p53-inducible nuclear protein
1, is involved in the promotion of apoptosis in response to DNA damage. Aberrant expression
of the gene is associated with pancreatic ductal adenocarcinomas and HTLV-related
T cell leukemia.;
NCIt note : Expression of the TP53INP1 gene can be induced by adriamycin, gamma irradiation and
hydrogen peroxide, in a p53-dependent way. Lower expression levels are induced by
ultraviolet radiation. (UniProt); The TP53INP1 gene has two distinct products that are the result of alternative splicing.;