Levothyroxine Sodium

Preferred Label : Levothyroxine Sodium;

NCIt synonyms : Therapeutic Levothyroxine;

NCIt related terms : Sodium levothyroxine; Thyroid hormone replacement;

NCIt definition : The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects.;

UNII : 9J765S329G;

InChIKey : JMHCCAYJTTWMCX-QWPJCUCISA-M;

CAS number : 25416-65-3;

Drug name : Synthroid; Levothroid;

Chemical formula : C15H10I4NO4.Na.H2O;

NSC code : 36397;

Codes from synonyms : NSC0259940;

Details

Origin ID

C888;

UMLS CUI

C0079691;

See also inter- (CISMeF)
- Levothyroxine sodium preparation (product) [Inactive SNOMED CT concept]
- levothyroxine sodium preparation [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Levothyroxine Sodium [International Nonproprietary Name]
- Levothyroxine sodium [ICD-11 Extension code]
- Levothyroxine sodium preparation (product) [Inactive SNOMED CT concept]
- levothyroxine sodium [ATC Code]
- levothyroxine sodium [MeSH concept]
- levothyroxine sodium preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- levothyroxine sodium [ATC Code]
Validated automatic mappings to NTBT
- Thyroxine [LOINC component]
- Thyroxine [MedDRA Preferred Term]
- Thyroxine (substance) [SNOMED CT concept]
- thyroxine [MeSH Descriptor]
- thyroxine [SNOMED Notion]
- thyroxine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HL Authorized Value Terminology [NCIt concept]
- HL Concomitant Medication Table [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Levothyroxine [NCIt concept]
is_salt_form_of
- Levothyroxine [NCIt concept]

Keyword's position in hierarchy(ies) :

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