NCIt definition : A concentrate of protein C, a vitamin K-dependent, heterodimeric plasma glycoprotein
and serine protease that is normally synthesized in the liver, that can be used as
an anticoagulant in patients with congenital protein C deficiency. Upon intravenous
administration, protein C concentrate replaces missing endogenous protein C. Protein
C is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface
to activated Protein C (APC). APC inactivates factors Va and VIIIa, which leads to
a decrease in thrombin formation. APC also has profibrinolytic effects. The protein
C pathway plays an important role in the regulation of blood coagulation.;
UNII : 3Z6S89TXPW;
CAS number : 60202-16-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 60202-16-6
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