NCIt definition : A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine
phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in
inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate
amidotransferase, thereby inhibiting purine synthesis. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;
UNII : FTK8U1GZNX;
InChIKey : VOXBZHOHGGBLCQ-UHFFFAOYSA-N;
CAS number : 5580-03-0;
Drug name : Lanvis; Tabloid;
Molecule name : BW 5071; X 27; WR-1141; Wellcome U3B;
Chemical formula : C5H5N5S.H2O;
NSC code : 752;
Codes from synonyms : CDR0000046765; 06268; NSC0000752; NSC0052758; 489;