Tetradecanoylphorbol Acetate

Preferred Label : Tetradecanoylphorbol Acetate;

NCIt synonyms : Phorbol Myristate Acetate; Lonomycin; 12-O-tetradecanoylphorbol-13-acetate; PMA; TPA (Phorbol Ester);

NCIt related terms : TPA; PHORBOL 12-MYRISTATE 13-ACETATE DIESTER;

NCIt definition : A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.;

UNII : NI40JAQ945;

InChIKey : PHEDXBVPIONUQT-RGYGYFBISA-N;

CAS number : 16561-29-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 16561-29-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C36H56O8;

NSC code : 262244;

ChEBI ID : CHEBI:37537;

Codes from synonyms : CDR0000663334; CDR0000044864; CDR0000046763;

Details

Origin ID

C866;

UMLS CUI

C0039654;

Automatic exact mappings (from CISMeF team)
- 12-O-tetradecanoylphorbol-1,3-acetate [MeSH concept]
- 12-O-tetradecanoylphorbol-1,3-acetate [MeSH Supplementary Concept]
- 4-methoxyamphetamine (substance) [SNOMED CT concept]
- Plasminogen activator, tissue [OMIM gene]
- Progressive muscular atrophy [ORDO Disease]
- Progressive muscular atrophy [ICD-11 Subcategory]
- lonomycin A [MeSH concept]
- posterior mesenteric artery [UBERON concept]
- reproductive techniques, assisted [MeSH Descriptor]
- taurine-pyruvate aminotransferase activity [GO term]
Currated CISMeF NLP mapping
- lonomycin [MeSH concept]
- lonomycin [MeSH Supplementary Concept]
- tetradecanoylphorbol acetate [Substance BNPC]
- tetradecanoylphorbol acetate [MeSH Descriptor]
- tetradecanoylphorbol acetate [MeSH concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tetradecanoylphorbol acetate [Substance BNPC]
- tetradecanoylphorbol acetate [MeSH Descriptor]
- tetradecanoylphorbol acetate [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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