Preferred Label : Silmitasertib Sodium;
NCIt synonyms : CK2 Inhibitor CX-4945; 5-((3-chlorophenyl)amino)-benzo(c)-2,6-naphthyridine-8-carboxylic Acid Sodium Salt;
NCIt definition : The sodium salt form of silmitasertib, an orally bioavailable small-molecule inhibitor
of the enzyme casein kinase II (CK2), with potential antineoplastic, anti-viral and
immunomodulatory activities. Upon oral administration, silmitasertib selectively binds
to and inhibits the activity of CK2. This may inhibit proliferation of CK2-expressing
tumor cells, and may also inhibit the replication of severe acute respiratory syndrome
coronavirus-2 (SARS-COV-2). In addition, this may restore normal host cell cytokine
regulation, prevent cytokine storm and suppress the hyperactivation of the innate
immune system. CK2, a protein kinase often overexpressed in a variety of cancer cell
types, appears to be correlated with malignant transformation, tumor growth and survival.
CK2 regulates a diverse array of pro-survival cellular processes including epidermal
growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling,
Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the
activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA
repair. CK2 is upregulated by SARS-COV-2 and is associated with SARS-COV-2 viral replication
and the development of cytokine storm.;
UNII : N1E607PU86;
InChIKey : ODDAAPQSODILSN-UHFFFAOYSA-M;
CAS number : 1309357-15-0;
Molecule name : CX-4945 Sodium; CX 4945 Sodium;
Chemical formula : C19H11ClN3O2.Na;
Origin ID : C85460;
UMLS CUI : C2827683;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
