Preferred Label : Silmitasertib;
NCIt synonyms : 5-((3-chlorophenyl)amino)-benzo(c)-2,6-naphthyridine-8-carboxylic Acid;
NCIt definition : An orally bioavailable small-molecule inhibitor of the enzyme casein kinase II (CK2),
with potential antineoplastic, anti-viral and immunomodulatory activities. Upon oral
administration, silmitasertib selectively binds to and inhibits the activity of CK2.
This may inhibit proliferation of CK2-expressing tumor cells, and may also inhibit
the replication of severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). In
addition, this may restore normal host cell cytokine regulation, prevent cytokine
storm and suppress the hyperactivation of the innate immune system. CK2, a protein
kinase often overexpressed in a variety of cancer cell types, appears to be correlated
with malignant transformation, tumor growth and survival. CK2 regulates a diverse
array of pro-survival cellular processes including epidermal growth factor receptor
(EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery,
hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1
and MDC1, two mediator/adaptor proteins that are essential for DNA repair. CK2 is
upregulated by SARS-COV-2 and is associated with SARS-COV-2 viral replication and
the development of cytokine storm.;
UNII : C6RWP0N0L2;
InChIKey : MUOKSQABCJCOPU-UHFFFAOYSA-N;
CAS number : 1009820-21-6;
Molecule name : CX 4945; CX-4945;
Chemical formula : C19H12ClN3O2;
Origin ID : C98054;
UMLS CUI : C3273788;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
