Suramin - CISMeF

Preferred Label : Suramin;

NCIt definition : A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.;

UNII : 6032D45BEM;

InChIKey : FIAFUQMPZJWCLV-UHFFFAOYSA-N;

CAS number : 145-63-1;

Chemical formula : C51H40N6O23S6;

ChEBI ID : CHEBI:45906;

Codes from synonyms : CDR0000045271; 45472;

Details

Origin ID

C853;

UMLS CUI

C0038880;

Automatic exact mappings (from CISMeF team)
- Product containing suramin (medicinal product) [SNOMED CT concept]
- Suramin sodium [ICD-11 Extension code]
CISMeF manual mappings
- Suramin (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- suramin [MeSH Descriptor]
False automatic mappings
- suramin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing suramin (medicinal product) [SNOMED CT concept]
- Suramin (substance) [SNOMED CT concept]
- suramin [MeSH concept]
- suramin [MeSH Descriptor]
chemical_or_drug_affects_cell_type_or_tissue
- Endothelial Cell [NCIt concept]
- Endothelium [NCIt concept]
chemical_or_drug_affects_gene_product
- Heparin Binding Growth Factor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Growth Factor Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Intercellular Communication Induction [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Suramin Sodium [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Heparin Binding Growth Factor [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Aminoglutethimide/Hydrocortisone/Suramin [NCIt concept]
- Aminoglutethimide/Suramin [NCIt concept]
- Carboplatin/Paclitaxel/Suramin [NCIt concept]
- Docetaxel/Suramin [NCIt concept]
- Doxorubicin/Suramin [NCIt concept]
- Flutamide/Goserelin/Suramin [NCIt concept]
- Flutamide/Hydrocortisone/Suramin [NCIt concept]
- Flutamide/Leuprolide/Somatuline/Suramin [NCIt concept]
- Flutamide/Leuprolide/Suramin [NCIt concept]
- Gemcitabine/Suramin [NCIt concept]
- Hydrocortisone/Suramin [NCIt concept]
- Leuprolide/Suramin [NCIt concept]
- Paclitaxel/Suramin [NCIt concept]
- Pentoxifylline/Suramin/Thiotepa [NCIt concept]
- Somatuline/Suramin [NCIt concept]
- Suramin/Topotecan [NCIt concept]
is_free_acid_or_base_form_of
- Suramin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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