Suramin Sodium

Preferred Label : Suramin Sodium;

NCIt synonyms : 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt;

NCIt related terms : Germanin; Sodium suramin; Bayer 205; Fourneau 309; Suramin Hexasodium; 309 F; Naganol; Antrypol; Naganin; Moranyl;

NCIt definition : A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.;

UNII : 89521262IH;

InChIKey : VAPNKLKDKUDFHK-UHFFFAOYSA-H;

CAS number : 129-46-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 129-46-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : 309 F; Antrypol; Naganol; Naphuride; Germanin; Fourneau 309; Naganin; Naganinum; Metaret; Moranyl; Belganyl;

Molecule name : CI-1003; Bayer 205;

Chemical formula : C51H34N6O23S6.6Na;

NSC code : 34936;

Codes from synonyms : 30140; NSC0034936;

Details

Origin ID

C1848;

UMLS CUI

C0813205;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Suramin sodium [ICD-11 Extension code]
- Suramin sodium (substance) [SNOMED CT concept]
- suramin sodium [ATC Code]
- suramin sodium [MeSH concept]
- suramin sodium [SNOMED Notion]
Validated automatic mappings to BTNT
- suramin sodium [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Endothelial Cell [NCIt concept]
- Endothelium [NCIt concept]
chemical_or_drug_affects_gene_product
- Heparin Binding Growth Factor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Growth Factor Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Intercellular Communication Induction [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Suramin [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Heparin Binding Growth Factor [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
is_salt_form_of
- Suramin [NCIt concept]

Keyword's position in hierarchy(ies) :

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