Preferred Label : Hsp90 Inhibitor HSP990;
NCIt synonyms : Oral Hsp90 Inhibitor HSP990;
NCIt definition : An orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential
antineoplastic activity. Hsp90 inhibitor Hsp990 binds to and inhibits the activity
of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins,
including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated
in a variety of tumor cells, is a molecular chaperone that plays a key role in the
conformational maturation, stability and function of oncogenic signaling proteins,
such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules
that are important in cell cycle regulation and/or immune responses.;
Molecule name : HSP990;
NCI Metathesaurus CUI : CL408658;
Origin ID : C82387;
UMLS CUI : C2830071;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
