Preferred Label : Pictilisib Bismesylate;
NCIt synonyms : 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine,
bimesylate salt; Pictilisib Dimesylate; Thieno(3,2-d)pyrimidine, 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)-1-piperazinyl)methyl)-4-(4-morpholinyl)-,
Methanesulfonate (1:2); GDC-0941 Dimesylate; GDC-0941 Bismesylate; PI3K Inhibitor GDC-0941 Bismesylate;
NCIt definition : The orally bioavailable bismesylate salt of pictilisib, a small molecule inhibitor
of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity.
Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner,
inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate
(PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition
of tumor cell growth, motility and survival in susceptible tumor cell populations.
Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis;
dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of
antineoplastic agents.;
UNII : G3D7HF2GS9;
InChIKey : RFRIKACSFOTIMU-UHFFFAOYSA-N;
CAS number : 957054-33-0;
NCI Metathesaurus CUI : CL408651;
Origin ID : C82380;
UMLS CUI : C4721994;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
