" /> Pictilisib - CISMeF





Preferred Label : Pictilisib;

NCIt synonyms : 2-(1H-indazol-4-yl)-6-((4-(methanesulfonyl)piperazin-1-yl)methyl)-4-(morpholin-4-yl)thieno(3,2-d)pyrimidine; 4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno(3,2-d)pyrimidin-4-yl)morpholine;

NCIt definition : A small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.;

UNII : ICY00EMP8P;

InChIKey : LHNIIDJUOCFXAP-UHFFFAOYSA-N;

CAS number : 957054-30-7;

Molecule name : GDC 0941; GDC-0941;

NCI Metathesaurus CUI : CL978574;

Codes from synonyms : 403;

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Keyword's position in hierarchy(ies) : arborescence

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24/05/2025


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