Preferred Label : Fosbretabulin;
NCIt synonyms : Combretastatin A-4 Phosphate; Phenol, 2-methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, Dihydrogen Phosphate; 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl Phosphate;
NCIt definition : A water-soluble prodrug derived from the African bush willow (Combretum caffrum) with
antineoplastic activity. Fosbretabulin is dephosphorylated to its active metabolite,
combretastatin A4, which binds to tubulin and inhibits microtubule polymerization,
resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial
cells detach from their substrata, tumor blood vessels collapse; the acute disruption
of tumor blood flow may result in tumor necrosis.;
UNII : I5590ES2QZ;
InChIKey : WDOGQTQEKVLZIJ-WAYWQWQTSA-N;
CAS number : 222030-63-9;
Chemical formula : C18H21O8P;
Origin ID : C82378;
UMLS CUI : C0056154;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
