Preferred Label : Fosbretabulin Disodium;
NCIt synonyms : 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl Disodium Phosphate; Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, Dihydrogen Phosphate,
Disodium Salt; Combretastatin A4 Phosphate; Combretastatin A4 Disodium Phosphate;
NCIt definition : The disodium salt of a water-soluble phosphate derivative of a natural stilbenoid
phenol derived from the African bush willow (Combretum caffrum) with potential vascular
disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin
is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent
combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization,
resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this
agent disrupts the engagement of the endothelial cell-specific junctional molecule
vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/beta-catenin/Akt
signaling pathway, which may result in the inhibition of endothelial cell migration
and capillary tube formation. As a result of fosbretabulin's dual mechanism of action,
the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic
necrosis of tumor tissue.;
UNII : 702RHR475O;
InChIKey : VXNQMUVMEIGUJW-XNOMRPDFSA-L;
CAS number : 222030-63-9;
Molecule name : CA4DP;
Chemical formula : C18H19O8P.2Na;
Origin ID : C2503;
UMLS CUI : C0962508;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
