Preferred Label : Fosbretabulin Tromethamine;
NCIt synonyms : 1,3-Dihydroxy-2-(Hydroxymethyl)Propan-2-Aminium 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl
Hydrogen Phosphate; 1,3-Propanediol, 2-Amino-2-(Hydroxymethyl)-, Compd. With 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl
Dihydrogen Phosphate (1:1); CA4P;
NCIt definition : The tromethamine salt form of prodrug fosbretabulin, a water-soluble phosphate derivative
of a stilbenoid phenol derived from the African bush willow (Combretum caffrum) with
antineoplastic activities. Upon administration, fosbretabulin is dephosphorylated
to its active metabolite, combretastatin A4, which targets and binds to tubulin dimers
and prevents microtubule polymerization, thereby resulting in mitotic arrest and apoptosis
in endothelial cells. As apoptotic endothelial cells detach from their substrata,
tumor blood vessels collapse; the acute disruption of tumor blood flow may result
in tumor necrosis.;
UNII : GBW044919E;
InChIKey : FIDMEHCRMLKKPZ-YSMBQZINSA-N;
CAS number : 404886-32-4;
Drug name : Zybrestat;
Chemical formula : C18H21O8P.C4H11NO3;
Origin ID : C83721;
UMLS CUI : C2827157;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
