Preferred Label : Telotristat Etiprate;
NCIt synonyms : Ethyl 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pryrimidin-4-yl)-l-phenylalaninate
N-benzoylglycinate (1:1); TPH Inhibitor LX1032;
NCIt definition : An orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug,
with potential antiserotonergic activity. Upon administration, telotristat etiprate
is converted to its active moiety, telotristat (LP-778902), which binds to and blocks
the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT)
production and improvement of serotonin-mediated gastrointestinal effects such as
severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed
in carcinoid tumor cells.;
UNII : 3T25U84H4U;
InChIKey : XSFPZBUIBYMVEA-CELUQASASA-N;
CAS number : 1137608-69-5;
Drug name : Xermelo;
Molecule name : LX1032 Hippurate; LX1606 Hippurate;
Chemical formula : C27H26ClF3N6O3.C9H9NO3;
NCI Metathesaurus CUI : CL1773665;
Origin ID : C81941;
UMLS CUI : C2825840;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
