Telotristat - CISMeF

Preferred Label : Telotristat;

NCIt definition : A tryptophan hydroxylase (TPH) inhibitor, with potential anti-serotonergic activity. Upon administration, telotristat binds to and inhibits the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.;

UNII : 381V4FCV2Z;

InChIKey : NCLGDOBQAWBXRA-PGRDOPGGSA-N;

CAS number : 1033805-28-5;

NCI Metathesaurus CUI : CL553881;

Codes from synonyms : 483;

Details

Origin ID

C152549;

UMLS CUI

C3884837;

Automatic exact mappings (from CISMeF team)
- telotristat [ATC Code]
Currated CISMeF NLP mapping
- Telotristat (substance) [SNOMED CT concept]
- telotristat [MeSH Supplementary Concept]
- telotristat [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing telotristat (medicinal product) [SNOMED CT concept]
- Telotristat (substance) [SNOMED CT concept]
- telotristat [ATC Code]
- telotristat [MeSH concept]
- telotristat [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Telotristat Etiprate [NCIt concept]
is_free_acid_or_base_form_of
- Telotristat Etiprate [NCIt concept]

Keyword's position in hierarchy(ies) :

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