Lenapenem - CISMeF

Preferred Label : Lenapenem;

NCIt synonyms : ( )-(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-3-(((3S,5S)-5-((R)-1-hydroxy-3-(methylamino)propyl)-3-pyrrolidinyl)thio)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid;

NCIt definition : A broad-spectrum, carbapenem antibiotic with bactericidal activity. Lenapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This inhibition weakens the bacterial cell wall and leads to lytic cell death in a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens.;

UNII : D6NBQ3H12U;

InChIKey : PZLOCBSBEUDCPF-YJIVIRPOSA-N;

CAS number : 149951-16-6;

Chemical formula : C18H29N3O5S;

NCI Metathesaurus CUI : CL474519;

Details

Origin ID

C81662;

UMLS CUI

C5886866;

Currated CISMeF NLP mapping
- Carbapenem (substance) [SNOMED CT concept]
- carbapenems [ATC Code]
- carbapenems [MeSH Descriptor]
- carbapenems [MeSH concept]
See also inter- (CISMeF)
- Product containing carbapenem (product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Carbapenem [LOINC component]
- Carbapenem (substance) [SNOMED CT concept]
- Product containing carbapenem (product) [SNOMED CT concept]
- carbapenems [ATC Code]
- carbapenems [MeSH concept]
- carbapenems [MeSH Descriptor]
Validated automatic mappings to BTNT
- Carbapenem [LOINC component]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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