NCIt definition : An orally bioavailable thromboxane (TxA2) and prostaglandin H2 (PGH2) (TP) receptor
antagonist, with anti-thrombotic, anti-hypertensive, anti-asthmatic and potential
anti-metastatic activities. Upon administration, ifetroban targets and binds to TxA2
and PGH2 receptors, thereby preventing the activity of both TxA2 and PGH2 and disrupting
their downstream signaling pathways. This prevents platelet activation, aggregation
and thrombosis. It also prevents vascular constriction and causes vasodilation. In
addition, as cancer cells use platelets to metastasize to different parts of the body,
ifetroban can reduce the stickiness of the platelets and prevent metastasis. TxA2
causes vascular contraction and platelet activation.;