Preferred Label : Ifetroban Sodium;
NCIt synonyms : Benzenepropanoic Acid, 2-((3-(4-((Pentylamino)carbonyl)-2-oxazolyl)-7-oxabicyclo(2.2.1)hept-2-yl)methyl)-,
Monosodium Salt, (1S-(Exo,Exo))-;
NCIt definition : The sodium salt form of ifetroban, an orally bioavailable thromboxane (TxA2) and prostaglandin
H2 (PGH2) (TP) receptor antagonist, with anti-thrombotic, anti-hypertensive, anti-asthmatic
and potential anti-metastatic activities. Upon administration, ifetroban targets and
binds to TxA2 and PGH2 receptors, thereby preventing the activity of both TxA2 and
PGH2 and disrupting their downstream signaling pathways. This prevents platelet activation,
aggregation and thrombosis. It also prevents vascular constriction and causes vasodilation.
In addition, as cancer cells use platelets to metastasize to different parts of the
body, ifetroban can reduce the stickiness of the platelets and prevent metastasis.
TxA2 causes vascular contraction and platelet activation.;
UNII : 48IJA0E92C;
InChIKey : WOHSQDNIXPEQAE-QBKVZTCDSA-M;
CAS number : 156715-37-6;
Chemical formula : C25H31N2O5.Na;
Origin ID : C81569;
UMLS CUI : C2825686;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
