Preferred Label : Esketamine;
NCIt synonyms : L-Ketamine; Ketamine, S-;
NCIt definition : A cyclohexanone derivative and S-enantiomer of racemic ketamine, with analgesic, anesthetic
and antidepressant activities. Although the mechanism of action is not fully understood,
upon administration, esketamine targets, non-competitively binds to, and blocks N-methyl
D-aspartate (NMDA) receptors. This reduces pain perception, induces sedation, and
produce dissociative anesthesia.;
UNII : 50LFG02TXD;
InChIKey : YQEZLKZALYSWHR-ZDUSSCGKSA-N;
CAS number : 33643-46-8;
Chemical formula : C13H16ClNO;
ChEBI ID : CHEBI:60799;
Origin ID : C81400;
UMLS CUI : C2825616;
Currated CISMeF NLP mapping
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
concept_is_in_subset
https://www.has-sante.fr/jcms/p_3191469/fr/spravato
2020
false
false
false
France
esketamine
insurance, health, reimbursement
treatment outcome
adult
drug therapy, combination
depressive disorder, Treatment-Resistant
Esketamine
ketamine
antidepressive agents
administration, intranasal
Esketamine
antidepressive agents
evaluation of the transparency committee
Esketamine
Esketamine
---
https://www.ema.europa.eu/en/medicines/human/EPAR/spravato
2019
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
ketamine
ketamine
Esketamine
Esketamine
drug approval
europe
antidepressive agents
antidepressive agents
product surveillance, postmarketing
administration, intranasal
nasal sprays
adult
drug therapy, combination
depressive disorder, Treatment-Resistant
aged
drug interactions
pregnancy
breast feeding
receptors, n-methyl-d-aspartate
drug evaluation, preclinical
esketamine
Esketamine
Esketamine
---