Preferred Label : Methylnaltrexone Bromide;
NCIt related terms : Relistor;
NCIt definition : The bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with
selective, peripherally-acting mu-opioid receptor antagonistic activity. Methylnaltrexone
displaces opioids from peripheral opioid receptors in the gastrointestinal tract,
the bladder, and the skin, thereby reversing the opioid-related peripheral side-effects,
such as constipation, urinary retention, and pruritis, respectively. Unlike naltrexone
and due to the presence of a positively charged nitrogen atom in methylnaltrexone,
this agent does not cross the blood-brain barrier and does not affect the centrally-mediated
analgesic effect of opioids.;
Alternative definition : NCI-GLOSS: A drug used to relieve certain side effects caused by treatment with opiods
(pain killers similar to morphine), such as constipation (hard, dry stools), itching,
and low urine flow. Methylnaltrexone bromide binds to opioid receptors outside the
brain and may block the side effects of opioid drugs without affecting their ability
to relieve pain. Methylnaltrexone bromide is a type of peripheral opioid receptor
antagonist.;
UNII : RFO6IL3D3M;
InChIKey : IFGIYSGOEZJNBE-NQMNLMSRSA-N;
CAS number : 916055-92-0;
Drug name : Relistor;
Chemical formula : C21H26NO4.Br;
Codes from synonyms : CDR0000600466; CDR0000600465;
Origin ID : C80569;
UMLS CUI : C2343921;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
