Preferred Label : Methylnaltrexone;
NCIt synonyms : Quaternary Ammonium Naltrexone; 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium;
NCIt definition : A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic
activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the
gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related
constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does
not cross the blood-brain barrier and does not affect the centrally-mediated analgesic
effect of opioids.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to relieve certain side effects caused
by treatment with opiods (pain killers similar to morphine), such as constipation
(hard, dry stools), itching, and low urine flow. Methylnaltrexone binds to opioid
receptors outside the brain and may block the side effects of opioid drugs without
affecting their ability to relieve pain. Methylnaltrexone is a type of peripheral
opioid receptor antagonist.;
UNII : 0RK7M7IABE;
InChIKey : JVLBPIPGETUEET-WIXLDOGYSA-O;
CAS number : 83387-25-1;
Chemical formula : C21H26NO4;
Codes from synonyms : CDR0000560648;
Origin ID : C48403;
UMLS CUI : C0066411;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
