Cocaine - CISMeF

Preferred Label : Cocaine;

NCIt synonyms : (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl Benzoate;

NCIt definition : A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.;

UNII : I5Y540LHVR;

InChIKey : ZPUCINDJVBIVPJ-LJISPDSOSA-N;

CAS number : 50-36-2;

Chemical formula : C17H21NO4;

ChEBI ID : CHEBI:27958;

Details

Origin ID

C80153;

UMLS CUI

C0009170;

Automatic exact mappings (from CISMeF team)
- Cocaine [HPMULTI term]
- Cocaine [ICHI section]
- Cocaine-induced acrocyanosis and livedo reticularis (disorder) [SNOMED CT concept]
- Narcotic drugs [UNESCO concept]
- Poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified, undetermined intent [ICD-10 category (who)]
False automatic mappings
- Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified [ICD-10 category (who)]
- Cocaine [ICD-10 Sub-category (who)]
- Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified [ICD-10 category (who)]
- Poisoning by, adverse effect of and underdosing of cocaine [ICD-10 Sub-category]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Benzoylmethylecgonine (substance) [SNOMED CT concept]
- Cocaine [ICD-10 Sub-category (who)]
- Cocaine [LOINC component]
- Cocaine (substance) [SNOMED CT concept]
- Product containing cocaine (medicinal product) [SNOMED CT concept]
- cocaine [ATC Code]
- cocaine [ATC Code]
- cocaine [ATC Code]
- cocaine [ATC Code]
- cocaine [MeSH concept]
- cocaine [MedlinePlus Topic]
- cocaine [MeSH Descriptor]
- cocaine [SNOMED Notion]
Validated automatic mappings to BTNT
- cocaine [ATC Code]
- cocaine [ATC Code]
- cocaine [ATC Code]
- cocaine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Cocaine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Cocaine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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