Preferred Label : Immunotherapy Regimen MKC-1106-MT;
NCIt synonyms : MKC-1106-MT;
NCIt definition : An immunotherapy regimen containing three components: a plasmid encoding portions
of the two melanoma-associated antigens Melan A (also called MART-1) and tyrosinase
and two synthetic analogs of Melan-A and tyrosinase antigen epitopes with potential
immunostimulating and antitumor activities. First, the plasmid is injected directly
into lymph nodes in order to sensitize or prime antigen-presenting cells (APCs) and
central memory T cells in lymph nodes to plasmid-expressed Melan A and tyrosinase.
After several priming injections with plasmids, the Melan A and tyrosinase synthetic
epitope analogs are injected directly into lymph nodes; upon binding to major histocompatibility
complex (MHC) molecules on APC cell surfaces, these synthetic epitope analogs may
stimulate a primed cytotoxic T lymphocyte (CTL) response against melanoma tumor cells,
resulting in tumor cell lysis. Melan-A and tyrosinase are overexpressed by melanoma
tumor cells.;
NCI Metathesaurus CUI : CL386958;
Origin ID : C77971;
UMLS CUI : C2697965;
Semantic type(s)
- concept_is_in_subset
- has_target
