Preferred Label : Immunotherapy Regimen MKC-1106-MT;
NCIt synonyms : MKC-1106-MT;
NCIt definition : A regimen containing three components: a plasmid encoding portions of the two melanoma-associated
antigens Melan A (also called MART-1) and tyrosinase and two synthetic analogs of
Melan-A and tyrosinase antigen epitopes with potential immunostimulating and antitumor
activities. First, the plasmid is injected directly into lymph nodes in order to sensitize
or prime antigen-presenting cells (APCs) and central memory T cells in lymph nodes
to plasmid-expressed Melan A and tyrosinase. After several priming injections with
plasmids, the Melan A and tyrosinase synthetic epitope analogs are injected directly
into lymph nodes; upon binding to major histocompatibility complex (MHC) molecules
on APC cell surfaces, these synthetic epitope analogs may stimulate a primed cytotoxic
T lymphocyte (CTL) response against melanoma tumor cells, resulting in tumor cell
lysis. Melan-A and tyrosinase are overexpressed by melanoma tumor cells.;
NCI Metathesaurus CUI : CL386958;
Origin ID : C77971;
UMLS CUI : C2697965;
Semantic type(s)
- concept_is_in_subset
- has_target
