Preferred Label : Darunavir Ethanolate;
NCIt definition : The ethanolate form of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease
nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir
selectively targets and binds to the active site of HIV-1 protease, and inhibits the
dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic
cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition
leads to the production of immature, non-infectious viral proteins that are unable
to form mature virions, and prevents HIV replication.;
UNII : 33O78XF0BW;
InChIKey : QWSHKNICRJHQCY-VBTXLZOXSA-N;
CAS number : 635728-49-3;
Drug name : Prezista;
Molecule name : TMC114;
Chemical formula : C27H37N3O7S.C2H6O;
Origin ID : C77389;
UMLS CUI : C1725651;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
