Darunavir - CISMeF

Preferred Label : Darunavir;

NCIt synonyms : TMC114; (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate;

NCIt definition : A human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication.;

UNII : YO603Y8113;

InChIKey : CJBJHOAVZSMMDJ-HEXNFIEUSA-N;

CAS number : 206361-99-1;

Chemical formula : C27H37N3O7S;

ChEBI ID : CHEBI:367163;

Details

Origin ID

C65364;

UMLS CUI

C1435444;

CISMeF manual mappings
- Darunavir [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Darunavir [MeSH Descriptor]
- Darunavir [LOINC component]
- Darunavir (substance) [SNOMED CT concept]
- Product containing darunavir (medicinal product) [SNOMED CT concept]
- darunavir [ATC Code]
- darunavir [MeSH concept]
Validated automatic mappings to BTNT
- darunavir [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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