Ticagrelor - CISMeF

Preferred Label : Ticagrelor;

NCIt synonyms : (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;

NCIt definition : An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation.;

UNII : GLH0314RVC;

InChIKey : OEKWJQXRCDYSHL-FNOIDJSQSA-N;

CAS number : 274693-27-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 274693-27-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Brilinta; Thioxlant-6C; Brilique; Ticalog;

Molecule name : AR-C126532XX; AZD6140;

Chemical formula : C23H28F2N6O4S;

Codes from synonyms : 492;

Details

Origin ID

C76404;

UMLS CUI

C1999375;

Automatic exact mappings (from CISMeF team)
- Ticagrelor [ICD-11 Extension code]
CISMeF manual mappings
- Ticagrelor (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing ticagrelor (medicinal product) [SNOMED CT concept]
- brilinta [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing ticagrelor (medicinal product) [SNOMED CT concept]
- Ticagrelor [MeSH Descriptor]
- Ticagrelor [MeSH concept]
- Ticagrelor (substance) [SNOMED CT concept]
- ticagrelor [ATC Code]
- ticagrelor [International Nonproprietary Name]
Validated automatic mappings to BTNT
- ticagrelor [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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