Preferred Label : Aderbasib;
NCIt synonyms : Methyl (6S,7S)-7-(Hhydroxyamino)carbonyl)-6-((4-phenylpiperazin-1-yl)carbonyl)-5-azaspiro(2.5)octane-5-carboxylate; 5-Azaspiro(2.5)octane-5-carboxylic Acid, 7-((Hydroxyamino)carbonyl)-6-((4-phenyl-1-piperazinyl)carbonyl)-,
Methyl Ester, (6S,7S)-; Sheddase Inhibitor INCB007839;
NCIt definition : An orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family
of multifunctional membrane-bound proteins with potential antineoplastic activity.
Aderbasib represses the metalloproteinase 'sheddase' activities of ADAM10 and ADAM17,
which may result in the inhibition of tumor cell proliferation. The metalloproteinase
domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the
cell membrane, releasing or shedding soluble protein etcodomains from the cell surface;
the disintegrin domains of these multifunctional proteins interact with various components
of the extracellular matrix (ECM). ADAM10 processes particular epithelial growth factor
receptor (EGFR) ligands and appears to regulate Notch signaling through the cleavage
of Notch and its related ligand delta-like ligand-1 (Dll-1). ADAM17 (also known as
Tumor necrosis factor-Converting Enzyme or TACE) is involved in processing tumor necrosis
factor (TNF) from its membrane bound precursor to its soluble circulating form and
in processing ligands for the epidermal growth factor receptor (EGFR) family.;
UNII : V9YL6NEJ3G;
InChIKey : DJXMSZSZEIKLQZ-IRXDYDNUSA-N;
CAS number : 791828-58-5;
Molecule name : INCB007839; INCB7839;
Chemical formula : C21H28N4O5;
Origin ID : C76115;
UMLS CUI : C2700364;
Semantic type(s)
- concept_is_in_subset
- has_target
