Hemoglobin Subunit Alpha

Preferred Label : Hemoglobin Subunit Alpha;

NCIt synonyms : Alpha-Globin; Hemoglobin Alpha Chain; Alpha Globin; HBA;

NCIt definition : Hemoglobin subunit alpha (142 aa, 15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of oxygen from the lungs to other organs and tissues.;

NCIt note : Two alpha chains plus two beta chains constitute Hemoglobin A (HbA), which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. (Entrez Gene);

Détails

Origin ID

C75434;

UMLS CUI

C0544482;

Automatic exact mappings (from CISMeF team)
- alphaglobin [MeSH concept]
- immunoglobulins, intravenous [MeSH Descriptor]
Currated CISMeF NLP mapping
- alpha-Globins [MeSH Descriptor]
- alpha-Globins [MeSH concept]
False automatic mappings
- alpha(A) globin [MeSH concept]
- alpha(A) globin [MeSH Supplementary Concept]
OMIM relation
- Hemoglobin--alpha locus 1 [OMIM gene]
- Hemoglobin--alpha locus 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HBA1 Gene [NCIt concept]
- HBA2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Erythrocyte [NCIt concept]
gene_product_has_gene_product_variant
- HBA Protein Variant [NCIt concept]
- HBA2 NP_000508.1:p.*143Qext*31 [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_physical_part_of
- Hemoglobin A1 [NCIt concept]
- Hemoglobin A2 [NCIt concept]
- Hemoglobin C [NCIt concept]
- Hemoglobin F [NCIt concept]
- Hemoglobin S [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alpha Thalassemia [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Transport Process [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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