Puromycin Hydrochloride

Preferred Label : Puromycin Hydrochloride;

NCIt definition : The hydrochloride salt form of puromycin, an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; it is used as an antibiotic in cell culture.;

UNII : PGN54228S5;

InChIKey : MKSVFGKWZLUTTO-FZFAUISWSA-N;

CAS number : 58-58-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 58-58-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H29N7O5.2HCl;

Details

Origin ID

C75148;

UMLS CUI

C0282329;

Automatic exact mappings (from CISMeF team)
- puromycin [MeSH Descriptor]
Currated CISMeF NLP mapping
- puromycin hydrochloride [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- puromycin hydrochloride [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Puromycin [NCIt concept]
is_salt_form_of
- Puromycin [NCIt concept]

Keyword's position in hierarchy(ies) :

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