Preferred Label : Aglatimagene Besadenovec;
NCIt synonyms : ADV-tk; Adenoviral Vector Encoding HSV Thymidine Kinase; Virafir;
NCIt definition : An adenoviral vector engineered to express the herpes simplex virus thymidine kinase
(HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine
analogue, possesses potential antineoplastic activity. Aglatimagene besadenovec is
transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic
acyclic guanosine analogues. Subsequently, a low dose of a synthetic acyclic guanosine
analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially
kill tumor cells containing the adenoviral vector and overexpressing HSV-tk. Release
of tumor-associated antigens (TAAs) by dying tumor cells may then stimulate an antitumor
cytotoxic T lymphocyte (CTL) response.;
UNII : 5Z72SSS34W;
CAS number : 1621271-62-2;
Drug name : ProstAtak; GliAtak;
Molecule name : CAN-2409; CAN 2409;
NCI Metathesaurus CUI : CL383459;
Origin ID : C73996;
UMLS CUI : C2347431;
Semantic type(s)
- concept_is_in_subset
- has_target
