Valacyclovir - CISMeF

Preferred Label : Valacyclovir;

NCIt synonyms : L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine; Valaciclovir; ValACV;

NCIt definition : The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.;

UNII : MZ1IW7Q79D;

InChIKey : HDOVUKNUBWVHOX-QMMMGPOBSA-N;

CAS number : 124832-26-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 124832-26-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zelitrex;

Chemical formula : C13H20N6O4;

ChEBI ID : CHEBI:35854;

Codes from synonyms : CDR0000269430; 525;

Details

Origin ID

C28235;

UMLS CUI

C0249458;

See also inter- (CISMeF)
- Product containing valaciclovir (medicinal product) [SNOMED CT concept]
- valacyclovir [Pharmacological Root]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing valaciclovir (medicinal product) [SNOMED CT concept]
- Valaciclovir (substance) [SNOMED CT concept]
- Valacyclovir [MeSH Descriptor]
- valACYclovir [LOINC component]
- valaciclovir [ATC Code]
- valacyclovir [Substance BNPC]
- valacyclovir [International Nonproprietary Name]
- valacyclovir [Pharmacological Root]
- valacyclovir [MeSH concept]
- valacyclovir [SNOMED Notion]
Validated automatic mappings to BTNT
- Valaciclovir hydrochloride (substance) [SNOMED CT concept]
- valaciclovir [ATC Code]
- valacyclovir [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Valacyclovir Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Valacyclovir Hydrochloride [NCIt concept]
is_target
- Aglatimagene Besadenovec [NCIt concept]

Keyword's position in hierarchy(ies) :

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