Preferred Label : Pentostatin;
NCIt synonyms : 2'-Deoxycoformycin; DCF; Pentostatine; Deoxycoformycin; (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;
NCIt related terms : Co-vidarabine; Covidarabine; Nipent; (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;
NCIt definition : A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus.
Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase
(ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells
of the lymphoid system with T-cells having higher activity than B-cells and T-cell
malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition
of ADA appears to result in elevated intracellular levels of dATP which may block
DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also
inhibit RNA synthesis and may selectively deplete CD26 lymphocytes. (NCI04);
Alternative definition : NCI-GLOSS: The active ingredient in a drug that is used to treat hairy cell leukemia
and is being studied in the treatment of other types of cancer. Pentostatin blocks
a protein needed for cell growth and may kill cancer cells. It is made by a bacterium.
It is a type of adenosine deaminase inhibitor.;
UNII : 395575MZO7;
InChIKey : FPVKHBSQESCIEP-JQCXWYLXSA-N;
CAS number : 53910-25-1; 63677-95-2;
Drug name : Nipent;
Molecule name : PD-81565; CI-825;
Chemical formula : C11H16N4O4;
NSC code : 218321; 247520;
Codes from synonyms : NSC0247520; CDR0000618582; CDR0000045190; NSC0218321; 397;
Origin ID : C732;
UMLS CUI : C0030896;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
