" /> Fludrocortisone - CISMeF





Preferred Label : Fludrocortisone;

NCIt synonyms : Fludrocortisone Base;

NCIt related terms : Florinef;

NCIt definition : A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na permeability in cells, thereby enhancing Na reabsorption and water retention as well as increasing K , H excretion.;

Alternative definition : NCI-GLOSS: A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.;

UNII : U0476M545B;

InChIKey : AAXVEMMRQDVLJB-BULBTXNYSA-N;

CAS number : 127-31-1;

Chemical formula : C21H29FO5;

NSC code : 11318;

ChEBI ID : CHEBI:50885;

Codes from synonyms : NSC0011318; CDR0000045199; 52383;

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Keyword's position in hierarchy(ies) : arborescence

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28/05/2025


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