NCIt definition : The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and
antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds
to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates
the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit
phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic
acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids
are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor
agonist, this agent stimulates Na reabsorption and water retention and K and H
secretion in the distal tubules and collecting ducts of the kidney.;