" /> Fludrocortisone Acetate - CISMeF





Preferred Label : Fludrocortisone Acetate;

NCIt synonyms : Fludrocortisone; Florinef Acetate;

NCIt definition : The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na reabsorption and water retention and K and H secretion in the distal tubules and collecting ducts of the kidney.;

UNII : V47IF0PVH4;

InChIKey : SYWHXTATXSMDSB-GSLJADNHSA-N;

CAS number : 514-36-3;

Drug name : Florinef;

Chemical formula : C23H31FO6;

NSC code : 15186;

Codes from synonyms : NSC0015186;

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Keyword's position in hierarchy(ies) : arborescence

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29/05/2025


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