Omeprazole - CISMeF

Preferred Label : Omeprazole;

NCIt synonyms : 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; OMEP;

NCIt definition : A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H - K ) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.;

Alternative definition : NCI-GLOSS: A drug that inhibits gastric acid secretion.;

UNII : KG60484QX9;

InChIKey : SUBDBMMJDZJVOS-UHFFFAOYSA-N;

CAS number : 73590-58-6;

Drug name : Losec; Prilosec;

Molecule name : H168/68;

Chemical formula : C17H19N3O3S;

ChEBI ID : CHEBI:7772;

Codes from synonyms : CDR0000045450; 01015; 369;

Details

Origin ID

C716;

UMLS CUI

C0028978;

Automatic exact mappings (from CISMeF team)
- esomeprazole [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Omeprazole [ICD-11 Extension code]
- Omeprazole [LOINC component]
- Omeprazole (substance) [SNOMED CT concept]
- Product containing omeprazole (medicinal product) [SNOMED CT concept]
- omeprazole [ATC Code]
- omeprazole [Substance BNPC]
- omeprazole [MeSH Descriptor]
- omeprazole [SNOMED Notion]
- omeprazole [MeSH concept]
Validated automatic mappings to BTNT
- omeprazole [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 2C19 [NCIt concept]
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Omeprazole Magnesium [NCIt concept]
- Omeprazole Sodium [NCIt concept]
is_component_of_chemotherapy_regimen
- Amoxicillin/Clarithromycin/Omeprazole [NCIt concept]
- Bismuth Subcitrate/Metronidazole/Omeprazole/Tetracycline [NCIt concept]
- Clarithromycin/Omeprazole/Tinidazole [NCIt concept]
- Omeprazole/Porfimer Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Omeprazole Magnesium [NCIt concept]
- Omeprazole Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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