Nimustine - CISMeF

Preferred Label : Nimustine;

NCIt synonyms : N'-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea; ACNU; 3-((4-Amino-2-Methyl-5-Pyrimidinyl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea;

NCIt definition : A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. (NCI05);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of brain cancer. It belongs to the family of drugs called nitrosoureas.;

UNII : 0S726V972K;

InChIKey : VFEDRRNHLBGPNN-UHFFFAOYSA-N;

CAS number : 42471-28-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 42471-28-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nidran;

Chemical formula : C9H13ClN6O2;

Codes from synonyms : CDR0000455140; NSC0245382; 354;

Details

Origin ID

C693;

UMLS CUI

C0028096;

Automatic exact mappings (from CISMeF team)
- Nimustine [ICHI extension code]
Currated CISMeF NLP mapping
- Nimustine [ICD-11 Extension code]
- nimustine [Substance BNPC]
- nimustine [MeSH Descriptor]
- nimustine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nimustine [ICD-11 Extension code]
- nimustine [ATC Code]
- nimustine [Substance BNPC]
- nimustine [MeSH concept]
- nimustine [MeSH Descriptor]
Validated automatic mappings to BTNT
- nimustine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Nimustine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Nimustine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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