" /> Fidaxomicin - CISMeF





Preferred Label : Fidaxomicin;

NCIt synonyms : Difimicin; Clostomicin B1; Lipiarmycin A3; Tiacumicin B;

NCIt related terms : PAR-101; OPT-80;

NCIt definition : A narrow-spectrum, 18-membered macrolide antibiotic isolated from the actinomycete Dactylosporangium aurantiacum subsp. hamdenensis with potential antibacterial activity. Although the exact mechanism of action has yet to be fully elucidated, fidaxomicin may bind to and inhibit bacterial DNA-dependent RNA polymerase, thereby inhibiting the initiation of bacterial RNA synthesis. When orally administered, this agent is minimally absorbed into the systemic circulation, acting locally in the gastrointestinal tract. Fidaxomicin appears to be active against pathogenic Gram-positive bacteria, such as clostridia, enterococci, and staphylococci, but does not appear to be active against other beneficial intestinal bacteria.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of diarrhea caused by infection with Clostridium difficile (a type of bacteria that can grow without oxygen) in cancer patients. OPT-80 is a type of antibiotic.;

UNII : Z5N076G8YQ;

InChIKey : ZVGNESXIJDCBKN-UUEYKCAUSA-N;

CAS number : 873857-62-6; 56645-60-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 873857-62-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 56645-60-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Dificid;

Molecule name : PAR-101; OPT-80;

Chemical formula : C52H74Cl2O18;

Codes from synonyms : CDR0000559075; CDR0000559076; CDR0000537331;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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