NCIt definition : The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective,
cardioprotective, and antineoplastic activities. After hydrolysis to an active form
that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron,
limiting the formation of free radical-generating anthracycline-iron complexes, which
may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft
tissues. This agent also inhibits the catalytic activity of topoisomerase II, which
may result in tumor cell growth inhibition.;
Alternative definition : NCI-GLOSS: A drug used to treat severe side effects caused by certain anticancer drugs.
It is used under the brand name Totect to treat the toxic effects of an anticancer
drug that leaks from a vein into surrounding tissue and causes tissue damage. It is
also used under the brand name Zinecard to reduce heart damage in women given doxorubicin
for breast cancer that has spread. Dexrazoxane hydrochloride is also being studied
in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective
agent, and a type of topoisomerase inhibitor.;
UNII : 5346058Q7S;
InChIKey : BIFMNMPSIYHKDN-FJXQXJEOSA-N;
CAS number : 149003-01-0;
Drug name : Zinecard; Totect; Cardioxane;
Chemical formula : C11H16N4O4.HCl;
ChEBI ID : CHEBI:50224;
Codes from synonyms : CDR0000572249; CDR0000572245; CDR0000572255;