Preferred Label : Dexrazoxane;
NCIt synonyms : Razoxane ( )-form; ( )-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione); 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI); 2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI);
NCIt related terms : 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI); Soluble ICRF (L-isomer); ICRF-187; 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI);
NCIt definition : A bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic
activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic
acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating
anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated
oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic
activity of topoisomerase II, which may result in tumor cell growth inhibition.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat severe side effects caused
by certain anticancer drugs. Under the brand name Totect it is used to treat the toxic
effects of an anticancer drug that leaks from a vein into surrounding tissue and causes
tissue damage. Under the brand name Zinecard it is used to reduce heart damage in
women given doxorubicin for breast cancer that has spread. Dexrazoxane is also being
studied in the treatment of cancer. It is a type of cardioprotective agent, a type
of chemoprotective agent, and a type of topoisomerase inhibitor.;
UNII : 048L81261F;
InChIKey : BMKDZUISNHGIBY-ZETCQYMHSA-N;
CAS number : 24584-09-6;
Molecule name : ADR-529; ICRF-187; ADR 529; ICRF 187;
Chemical formula : C11H16N4O4;
NSC code : 169780;
ChEBI ID : CHEBI:50223;
Codes from synonyms : 06178; CDR0000045220; NSC0169780; 158;
Origin ID : C1333;
UMLS CUI : C0086444;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
