NCIt definition : The sodium salt form of mycophenolic acid (MPA), with immunosuppressing activity.
In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase
(IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation
of B and T lymphocytes. Relative to other cell types, lypmocytes are highly dependent
on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone
to MPA cytotoxicity.;