Preferred Label : Duloxetine Hydrochloride;
NCIt related terms : cymbalta;
NCIt definition : The hydrochloride salt of duloxetine, an orally bioavailable fluoxetine derivative
belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake
inhibitors (SNRIs), with central pain inhibitory, anxiolytic and antidepressant activities.
Upon oral administration, duloxetine selectively prevents the reuptake of 5-HT and
NE via transporter complexes on the pre-synaptic membrane, thereby increasing the
level of these neurotransmitters within the synaptic cleft. This potentiates serotonergic
and noradrenergic activities in the central nervous system (CNS), and alleviates anxiety,
depression, and neuropathy sensations, such as neuropathic pain.;
Alternative definition : NCI-GLOSS: A drug used to treat depression and peripheral neuropathy (pain, numbness,
tingling, burning, or weakness in the hands or feet) that can occur with diabetes.
It is also being studied in the treatment of peripheral neuropathy caused by certain
anticancer drugs. Duloxetine hydrochloride increases the amount of certain chemicals
in the brain that help relieve depression and pain. It is a type of serotonin and
norepinephrine reuptake inhibitor.;
UNII : 9044SC542W;
InChIKey : BFFSMCNJSOPUAY-LMOVPXPDSA-N;
CAS number : 136434-34-9;
Drug name : Cymbalta;
Chemical formula : C18H19NOS.HCl;
ChEBI ID : CHEBI:31526;
Codes from synonyms : CDR0000589398; CDR0000589399;
Origin ID : C65496;
UMLS CUI : C1505020;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
