Preferred Label : Duloxetine;
Alternative definition : NCI-GLOSS: A drug used to treat depression and peripheral neuropathy (pain, numbness,
tingling, burning, or weakness in the hands or feet) that can occur with diabetes.
It is also being studied in the treatment of peripheral neuropathy caused by certain
anticancer drugs. Cymbalta increases the amount of certain chemicals in the brain
that help relieve depression and pain. It is a type of serotonin and norepinephrine
reuptake inhibitor.; NCI: An orally bioavailable fluoxetine derivative belonging to the class of selective
serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs), with central
pain inhibitory, anxiolytic and antidepressant activities. Upon oral administration,
duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes
on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters
within the synaptic cleft. This potentiates serotonergic and noradrenergic activities
in the central nervous system (CNS), and alleviates anxiety, depression, and neuropathy
sensations, such as neuropathic pain.;
UNII : O5TNM5N07U;
InChIKey : ZEUITGRIYCTCEM-KRWDZBQOSA-N;
CAS number : 116539-59-4;
Chemical formula : C18H19NOS;
ChEBI ID : CHEBI:36795;
Codes from synonyms : CDR0000559443;
Origin ID : C65495;
UMLS CUI : C0245561;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
