Preferred Label : Duloxetine;
NCIt definition : An orally bioavailable fluoxetine derivative belonging to the class of selective serotonin
(5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs), with central pain inhibitory,
anxiolytic and antidepressant activities. Upon oral administration, duloxetine selectively
prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic
membrane, thereby increasing the level of these neurotransmitters within the synaptic
cleft. This potentiates serotonergic and noradrenergic activities in the central nervous
system (CNS), and alleviates anxiety, depression, and neuropathy sensations, such
as neuropathic pain.;
Alternative definition : NCI-GLOSS: A drug used to treat depression and peripheral neuropathy (pain, numbness,
tingling, burning, or weakness in the hands or feet) that can occur with diabetes.
It is also being studied in the treatment of peripheral neuropathy caused by certain
anticancer drugs. Cymbalta increases the amount of certain chemicals in the brain
that help relieve depression and pain. It is a type of serotonin and norepinephrine
reuptake inhibitor.;
UNII : O5TNM5N07U;
InChIKey : ZEUITGRIYCTCEM-KRWDZBQOSA-N;
CAS number : 116539-59-4;
Chemical formula : C18H19NOS;
ChEBI ID : CHEBI:36795;
Codes from synonyms : CDR0000559443;
Origin ID : C65495;
UMLS CUI : C0245561;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
