Preferred Label : Ciclesonide;
NCIt definition : A nonhalogenated, synthetic, inhaled corticosteroid (ICS) with anti-inflammatory and
potential antiviral activities. Upon administration by oral inhalation into the lungs,
ciclesonide (CIC) is converted by local esterases to its active metabolite desisobutyryl-ciclesonide
(des-CIC), which binds to intracellular glucocorticoid receptors (GRs). The ligand-bound
GRs regulate gene expressions, which lead to inhibitory activities against multiple
cell types, such as mast cells, eosinophils, basophils, lymphocytes, macrophages and
neutrophils, and various mediators associated with inflammation, such as histamine,
eicosanoids, leukotrienes and cytokines. In addition, ciclesonide may suppress the
replication of human coronavirus by targeting viral nonstructural protein 15 (NSP15).;
UNII : S59502J185;
InChIKey : LUKZNWIVRBCLON-GXOBDPJESA-N;
CAS number : 126544-47-6;
Drug name : Alvesco; Omnaris;
Chemical formula : C32H44O7;
Origin ID : C65326;
UMLS CUI : C0907850;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
