Auranofin - CISMeF

Preferred Label : Auranofin;

NCIt definition : An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.;

UNII : 3H04W2810V;

InChIKey : AUJRCFUBUPVWSZ-XTZHGVARSA-M;

CAS number : 34031-32-8;

Drug name : Ridaura;

Chemical formula : C20H34AuO9PS;

ChEBI ID : CHEBI:2922;

Details

Origin ID

C65242;

UMLS CUI

C0004320;

Currated CISMeF NLP mapping
- Auranofin [ICD-11 Extension code]
- Auranofin (substance) [SNOMED CT concept]
- Product containing auranofin (medicinal product) [SNOMED CT concept]
- auranofin [Substance BNPC]
- auranofin [MeSH Descriptor]
- auranofin [MeSH concept]
- auranofin [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Auranofin [ICD-11 Extension code]
- Auranofin (substance) [SNOMED CT concept]
- Product containing auranofin (medicinal product) [SNOMED CT concept]
- auranofin [ATC Code]
- auranofin [Substance BNPC]
- auranofin [MeSH Descriptor]
- auranofin [SNOMED Notion]
- auranofin [MeSH concept]
Validated automatic mappings to BTNT
- auranofin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Thioredoxin Reductase 2, Mitochondrial [NCIt concept]

Keyword's position in hierarchy(ies) :

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