Megestrol - CISMeF

Preferred Label : Megestrol;

NCIt synonyms : Compound 5071; Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-; MEG;

NCIt definition : A synthetic derivative of progesterone with antiestrogenic activity. Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates appetite in cachectic subjects.;

Alternative definition : NCI-GLOSS: A drug used to block estrogen and suppress the effects of estrogen and androgens. It is used to treat breast and endometrial cancer, and is being studied in the treatment of other types of cancer. It is also used to improve appetite in patients with cancer. Megestrol belongs to the group of hormones called progestins.;

UNII : EA6LD1M70M;

InChIKey : VXIMPSPISRVBPZ-NWUMPJBXSA-N;

CAS number : 3562-63-8;

Chemical formula : C22H30O3;

ChEBI ID : CHEBI:6722;

Codes from synonyms : CDR0000046617; 324;

Details

Origin ID

C630;

UMLS CUI

C0025175;

Currated CISMeF NLP mapping
- Megestrol [ICD-11 Extension code]
- Megestrol [ICHI extension code]
- Megestrol [SMS substance]
- Megestrol (substance) [SNOMED CT concept]
- megestrol [Substance BNPC]
- megestrol [MeSH Descriptor]
- megestrol [MeSH concept]
- megestrol [SNOMED Notion]
See also inter- (CISMeF)
- Product containing megestrol (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Hormone [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Megestrol [ICD-11 Extension code]
- Megestrol (substance) [SNOMED CT concept]
- Product containing megestrol (medicinal product) [SNOMED CT concept]
- megestrol [ATC Code]
- megestrol [ATC Code]
- megestrol [ATC Code]
- megestrol [Substance BNPC]
- megestrol [MeSH Descriptor]
- megestrol [MeSH concept]
- megestrol [SNOMED Notion]
Validated automatic mappings to BTNT
- megestrol [ATC Code]
- megestrol [ATC Code]
- megestrol [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Megestrol Acetate [NCIt concept]
has_target
- Progesterone Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Aminoglutethimide/Megestrol [NCIt concept]
- Cisplatin/Etoposide/Megestrol [NCIt concept]
- Dronabinol/Megestrol [NCIt concept]
- Interferon Alfa/Megestrol/Tamoxifen [NCIt concept]
- Megestrol/Omega-3 Fatty acids [NCIt concept]
is_free_acid_or_base_form_of
- Megestrol Acetate [NCIt concept]

Keyword's position in hierarchy(ies) :

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