Preferred Label : Megestrol Acetate;
NCIt synonyms : 6-Methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione Acetate; 6-Dehydro-6-methyl-17 alpha-acetoxyprogesterone; (9beta,10alpha)-17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione; 17 Alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione Acetate; Pallace;
NCIt related terms : Megace; Niagestin; 6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone; BDH 1298; 17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione; SC-10363; Ovaban; 6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone;
NCIt definition : The acetate salt form of megestrol, a synthetic derivative of the naturally occurring
female sex hormone progesterone with potential anti-estrogenic and antineoplastic
activity. Mimicking the action of progesterone, megestrol acetate binds to and activates
nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor
complex to be translocated to the nucleus where it binds to and promotes expression
of target genes. This leads to an alteration in protein synthesis, which modulates
cell growth of reproductive tissues. Due to the negative feedback mechanism seen with
progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary
gland, thereby leading to an inhibition of ovulation and an alteration in the cervical
mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from
the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells.;
Alternative definition : NCI-GLOSS: A drug used to block estrogen and suppress the effects of estrogen and
androgens. It is used to treat breast and endometrial cancer, and is being studied
in the treatment of other types of cancer. It is also used to improve appetite in
patients with cancer. Megace belongs to the group of hormones called progestins.;
UNII : TJ2M0FR8ES;
InChIKey : RQZAXGRLVPAYTJ-GQFGMJRRSA-N;
CAS number : 595-33-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 595-33-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Megestat; Megestil; Megace; Maygace; Niagestin;
Molecule name : SC-10363; BDH-1298;
Chemical formula : C24H32O4;
NSC code : 71423;
ChEBI ID : CHEBI:6723;
Codes from synonyms : NSC0071423; CDR0000413949; 06876;
Origin ID : C1156;
UMLS CUI : C0065879;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_component_of_chemotherapy_regimen
- is_salt_form_of
