NCIt definition : Beta-2-microglobulin protein (119 aa, 14 kDa) is encoded by the human B2M gene. This
protein plays a role in immune responses and is a key component of major histocompatibility
complex class I molecules. The protein is localized to the surface of cells and is
utilized as a prognostic marker in persons with cancers that involve white blood cells.
The polypeptide is also used as a marker in kidney damage diagnosis and in the detection
of viral infection.;
Alternative definition : NCI-GLOSS: A small protein normally found on the surface of many cells, including
lymphocytes, and in small amounts in the blood and urine. An increased amount in the
blood or urine may be a sign of certain diseases, including some types of cancer,
such as multiple myeloma or lymphoma.;